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18/Oct/2018
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National Academy of Sciences - Knee Osteoarthritis

Stem Cell Injections for Lower Back Pain

Case Study: Ken, 43.  Avid Golfer, Weight Lifter & Former College Athlete

Ken is a Brilliant,  43 year old entrepreneur from Philadelphia who recently visited us in Florida with a Major Game-Stopping problem. He had built his Fitness Business from one small gym,  into five thriving Fitness Centers that were ready to dominate the market and change many lives. A vision so important that he deserved all of our attentions.

But one problem was holding him back.


You guessed it … Back Pain.


Back pain was stopping his game.

Stem Cells For Lower Back Pain From Golf


Making him take a time out, when he was still ready to play. Making him ride the cart, when he really wanted to walk. Making him stop after 9 holes, instead of blazing through 18.  It hurt him both in business and on the links. Here is how we evaluated him and got him back-In-the-game.


Ken had one major problem: a nagging low back pain, which stopped him from enjoying everything that had helped him become the man he is. Yet, he still is the only man who created all this fitness business. He did not want to lose it all to back pain.


After completion of our unique, Comprehensive Medical Assessment (CMA) the origin of his pain was starkly elucidated.


The Medical Masters Way

Taking a note from from basic osteopathic medicine, and looking at the history and physical findings, we quickly realized that the patient will tell you what their medical problem is, if you just listen to them long enough. Next we did a proper, old school history and physical.


No computer can yet do that.  Yet.


The doctor does not control this process, even though she or he may think they do. The patient and their story control it all. The osteopathic way predates what is now called “Functional Medicine”.


We can see so far today, because we stand on the shoulders of Giants. Even if we don’t know who they were or what they contributed to human evolution.


Andrew Taylor Still M.D. was one of the earliest and biggest of those Giants in medicine, starting in 1892.  He envisioned and then created the healing system of Osteopathic Medicine. Less drugs, less surgery, more touching and healing the patient. Real medical leaders.


Hail to the Victors!

When taking the comprehensive history of Ken, we had to look far back in his life. All the way back to the origin of his pain. Discussing it and analyzing it is also therapeutic. The patient had seen a dozen doctors, yet none of his previous providers had let the patient tell his story, in his own way, and listened to understand. He finally was able to fully share the rocky journey he had endured.


Fact Check (See The Video)


Prescribing a True Regenerative treatment plan including stem cell therapy , nutritional support or intravenous rescue, should never be a one size fits all, never a routine approach.


It is not off the shelf, It cannot be: “off the shelf”.


Your exact cells at this time and place are the exact cells your body needs to heal itself.


The purpose of our individualized regenerative medicine approach is that it is specific to this patient at this time based on the needs of this patient.


It is not designed for the benefit of the Doctor, the payment involved or the chosen intervention.


If only mainstream medicine would learn from the patient, what the patient needs, not what the system needs.


It requires a careful diagnostic evaluation of the patient’s entire medical history.

Each person has a unique physiologic historic timeline that’s influenced by several traditional medical treatments over the years. These surgical or pharmaceutical approaches may work for a while but ultimately fail to address the root cause of disease and its messy effects.


This is the Medical Masters, Osteopathic way.


This was exactly the case in Ken’s dilemma.


“Dr. Coleman, I’m having pain in my lower lumbar area which has increased over the last month or so.   I went golfing yesterday and it aggravated the pain, mostly in my left hip. It’s a shooting, stabbing pain that leads to spasms and makes me tighten up,” he said.


Ken was obviously in peak shape for his age, having spent years playing athletic sports like football and golf. He certainly looks like a major fitness expert.


After detailed questions and additional orthopedic and neurological testing of the Spine and extremities, it emerged that two key incidents were the progenitors for his present condition.  They both happened decades ago.


The details of the  first event, that he only recalled with caring questioning , happened when he was  just 18 years old while lifting groceries out of his car.


“I was leaning over and pulling stuff out of my trunk. I suddenly felt my lower back spasm. It was a strange sensation that I have never felt. After that, it would flare up every once in a while. Now it's out of control” he said.


In fact, after further prodding, it emerged that over a period of decades he would recall sometimes getting up from a seated position only to find himself spasming, literally rocking his body and unsettling his balance.  


 Then, suddenly it would be gone, and things would be good for a while. What gives?


The second incident(s) involved athletic activities like golfing or lifting weights where he sporadically experienced a sharp tweak or pinching pain in his lower sacroiliac joint. This pain was separate and intermittent, but often related to the other disc related back pain.


After further investigation, it emerged that the pain evolved and spread to his shoulder blades.


“I almost felt like a knife had been stabbed behind the left shoulder.   I tried moving around to loosen it up, but this only made it worse, to the point where I started experiencing pins and needles in my fingers and even legs.   My legs and hands would go just go very weak,” he said. Nothing, including manipulation, and traction decompression helped.


An MRI would later reveal a herniated disk requiring several months of physical therapy which provided some short-term relief but never enough to stop the pain train.

He was eventually compelled to undertake a Microdiscectomy surgery,  which removes a small piece of bone over the nerve root with the goal of relieving the nerve entrapment. In theory, it should relieve the pain totally. In theory. But since the body is held together with an omnipresent connecting material called fascia, rarely is there one single problem that can be cured with the magic bullet approach.


This all too common,  but incredibly invasive procedure, to relieve the so-called “bulging disk” did work for a while,  but always, the pain would return, usually with a vengeance.


This really is a dilemma.


Ken confirmed that in the last five years he had seen a consistent increase in the stabbing pain and spasms, particularly when playing golf or moving  from sitting to the standing position.


Forget swinging a club.


The last two months had been particularly unpleasant until he saw an old friend of his, a physician who had seen Dr. Coleman for severe chronic pain in both shoulders.

“When I met Dr. Len, I couldn’t get out of my chair. I literally could not walk. The pain shot through my lower back and I had repeated pain spasms.”


It was at this meeting that Dr. Len mentioned the successful treatment he had undergone at Medical Masters.org.


Ken continued to stretch and use physical activity like golf in an attempt to get the blood flowing and his joints loose again.


Then, two weeks ago, he woke up and his world was frozen.

“I was shocked.  I could barely get out of bed and walk. I was in agony and literally bent over from the pain.”


This was the tipping point for his initial call to MedicalMasters.org, where we put him through a 100 Point Health Score and began to build a treatment strategy specific to Ken.


I informed Ken that once you experience disk issues it can have residual effects in surrounding joints and ligaments. This tightening effect along the lamina and adjacent vertebrae is also influenced by imbalances in muscle tone or general posture.  The fact that he experienced pain while in - or moving to - a standing position offered additional clues as to the possible problems.


Offering Hope. Not Hype. 


In his case, I believed that stem cell therapy involving the precise extraction of the patient’s own cellular cells including bone marrow (hematopoietic stem cells) and adipose derived stem cells (mesenchymal cells)  and its re-injection into the lumbar and sacroiliac joint. would assist in returning normal body function and reducing overall pain levels. These injections do not specifically target nerve roots, but can benefit Neurogenic pain coming from smaller nerves.


The joints, ligaments and trigger points, do get targeted. Specifically the lower lumbar facet joints (see link) are excellent targets in those with arthritis in the back.


The procedure took around three and one half hours to complete and Ken reported a positive mood immediately after the same-day treatment.


“I feel a little sore but overall really great.   I am super optimistic and excited. I am glad it’s done and look forward to the process of healing.  The entire medical team made me very comfortable before, during and after the process.”


This quick procedure,  which is done under local anesthesia only (level-1 anesthesia) is designed to be minimally risky while helping patients like Ken have less pain while performing daily activities with less limitations.     


Ken will now be monitored, coached, and encouraged over the next 6 to 9 months as part of a patient centered, systematic regenerative approach to healing the human body.  


This is more than he signed up for, and we are passionate about delivering it.


Why?  


Because we care, and it helps us and all of humanity to act on this higher level. It also feels really really good to us in the trenches.  This is our glory too. His improvement really matters to us.


While he may experience some physical discomfort over the next weeks, this is a common attribute of the healing process which includes powerful invisible cytokines at work helping with tissue regeneration.


Within a month of the procedure Ken should experience greater mobility and lower pain levels, signaling that this body’s own cells are at work strengthening the surrounding ligaments and tissue in his back.


We invite our readers to return to MedicalMasters.org or visit us on Facebook for follow ups on Kens’ recovery process.


We  hope he will be back on the golf course,


Going for that Hole in One.


Hail to the Victors!


They have earned it through blood, sweat and tears.

Naples Stem Cell Therapy - Golfing Case Study

18/Oct/2018
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Rebel Lilly, an active 50-year paddle boarder and outdoor enthusiast is no stranger to pain: She had undergone several past knee surgeries and additional procedures to remove tumors. However, when she pulled her shoulder out of position almost three months ago it put a stop to simple daily activities such as driving or simply sweeping the floor. Full patient video is further below.


Dr. Steve Coleman Doctor of Osteopathic Medicine,  MedicalMasters..org

What you will learn:

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    How regenerative programs differ from surgery
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    How pain and healing timelines can be accelerated
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    How stem cell injections impact inflammation, pain & range of motion
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    The novel use of Laser Therapy to support stem cell injections
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    Positive outcomes from same-day cellular therapies
Shoulder Tear From Paddleboarding

Worse, she was unable to enjoy her primary passion, paddle boarding, due to a severely restricted range of motion. Unable to raise her arm more than 10-20 degrees off her hip without screaming in pain, she faced the uncomfortable prospect of more orthopedic surgery to repair her torn rotator cuff with uncertain outcomes.

Barely able to move her arm or neck, she began researching possible alternatives.

After attending one of our previous Stem Cell Seminars in Bonita Springs, Rebel took the brave decision to try regenerative joint healing approaches encompassed in a Medicalmasters.org Stem Cell Injection program.

Dr. Coleman, a Doctor of Osteopathic Medicine, carefully compiled a 100-Point Health Score or Comprehensive Medical Assessment (CMA) of Rebel’s condition to determine her candidacy for the Stem Cell Program. Precise shoulder palpation and manipulation, along with MRI scans, confirmed an almost full shoulder tear which accounted for the severe pain and reduced mobility.

National Academy of Sciences - Knee Osteoarthritis

More About Shoulder Rotator Cuff Injuries

The Danger of Repetition

Repetitive motions in work and play, can lead to rotator cuff injuries. This includes occupations such as carpentry or sports such as CrossFit, where athletes perform high-rep pull ups on a regular basis. In Lilly’s case, paddle boarding, which involves short, similar strokes can also aggravate and put pressure on the shoulder joints if not done correctly or performed hundreds, if not thousands of times, during a calendar week.

Rebelling Against Pain

Her qualification by Dr. Coleman in the CMA, enabled her to undertake a same-day procedure to extract her bone marrow and fat adipose cells to galvanize rich regenerative stem cells containing Cytokines for accelerated joint repair. These were re-injected back into group of muscles and tendons that surround the shoulder joint, the so-called Rotator Cuff, which keeps the head of your upper arm bone firmly with the overall socket of the shoulder.

The 4 to 6-hour procedure allowed Rebel to go straight home following the stem cell injections.  In the days and weeks following the procedure, Rebel’s cells began their mission of rebuilding and re-invigorating the joint. While the healing process can be slightly uncomfortable during the first 14 days following the procedure, this is usually a normal sign that indicates the tissues and ligaments are responding to stem cell differentiation which leads to repair.

MedicalMasters.org used a systematic healing program to accelerate the healing process in Rebel’s shoulder joint.  This included precise physical therapy movements such as the wall crawl to increase mobility and range of motion. Rebel performed these 2-3 times per day to oxygenate the blood stimulate tissue repair.  MedicalMasters.org works closely with nearby rehabilitative clinics including Bonita Springs Sports & Physical Therapy Center and Therapy Clinics to align regenerative programs with new advances in physical rehabilitation.  This symbiotic relationship was described in one of our recent articles The Golden Age of Regenerative Medicine Unites Osteopathic Doctors, Physical Therapists & Compassionate Inventors.

Patient Success Story - Rebel Lilly

18/Oct/2018
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As we approach middle-age (or beyond) Americans are being forced to consider two symbiotic threats to their health which medical research indicates are teaming up to double the risk of heart disease while also limiting the quality of life: Heart disease and osteoarthritis.

By the time you read this, it’s estimated that 50 million adults have already been diagnosed with some type of arthritis including Degenerative Joint Disease (DJD) which is not curable, causes immense pain, and stops us enjoying daily activities such as walking, running or climbing stairs.

Traditionally, doctors tackle this growing disease with Non-Steroidal Anti-Inflammatory Drugs or NSAIDS, which while reducing the pain in the short-term inevitably limits the body’s ability to resolve inflammation over the longer-term.

Osteoarthritis Joint Pain


More alarmingly, a Canadian study involving 7743 people with osteoarthritis shows strong evidence that NSAID treatment increases congestive heart failure by nearly 49% while the risk for ischemic heart disease increased by 94.5%, and the risk for stroke increased by 93.3%. These results were supported by cross-referencing NSAID prescription dispensing records present in the Canadian healthcare database.

Cardiovascular Disease
These health risks are reflective of a non-regenerative approach to medical problems, which involve relying upon both NSAID and steroidal options (such as Cortisone) to treat the symptoms, not the problem.

This traditional methodology arguably leads to inevitable outcome(s) involving either heart surgery or joint replacement surgery, or both! While America is blessed with talented heart and orthopedic surgeons, who wishes to undergo invasive surgery which statistics show are not always successful, carrying both health and financial risks?

Our Osteopathic clinic, with its special emphasis on regenerative protocols such as Stem Cell Therapy, Prolotherapy, PRP and Laser Therapy, is in a unique position to screen and treat middle-aged Americans for both Osteoarthritis and cardiovascular risk factors, while limiting the use of NSAID and additionally minimizing the application of invasive joint surgery.

Early detection of both Osteoarthritis and cardiovascular disease are now considered top priorities in the America and something we take extremely seriously in our clinic.

We are obsessed with three primary objectives which we believe are the key drivers in ensuring a long and productive lifespan for our patients:

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    Prevention
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    Regeneration
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    Nutrition

Education, early detection of cardiovascular risk factors and an emphasis on non-surgical orthopedic protocols allows us to prevent side-effects from medication and surgery.

The use of Stem Cell Therapy and Laser Therapy allows us to accelerate joint healing and reduce pain, a novel regenerative approach which patients respond positively to.

Nutritional IV supplement programs along with doctor-guided weight loss systems allow us to positively impact your health over the long term.

These programs carefully guided by a Doctor of Osteopathic Medicine open up new opportunities to gently nurture, protect and heal the human body especially for adults, men and women, near or above, 45 years in age.

It’s important to remember that the study above and our approach encompassed under the regenerative programs are NOT intended to reflect a negative bias towards surgery, but rather a desire to explore alternatives and only resort to this option when absolutely necessary. 

It’s important to remember that the study above and our approach encompassed under the regenerative programs are NOT intended to reflect a negative bias towards surgery, but rather a desire to explore alternatives and only resort to this option when absolutely necessary.  These alternatives are reflected in our ​cellular therapy protocols, including Stem Cell Therapy, and new non-surgical techniques to stimulate joint healing such as Laser Surgery
The three circles of regenerative medicine

18/Oct/2018

Laurie Norman was scheduled for bi-lateral knee replacement. At the last moment, she decided to try MedicalMasters.org’s stem cell therapy program and the promise of regenerative medicine to keep her off the operating table.  A well known local dog breeder and dog show contestant, Laurie had for years been struggling with painful joint pain and restricted mobility as she pursued her vocation.   In this video, Laurie describes in her own words the results of the stem cell therapy program with Dr. Coleman and its impact on her quality of life.


18/Oct/2018
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When a former college football quarterback, with letters in 3 sports, throughout high school, walked through our doors complaining of chronic pain in both knees due to previous sports injuries, and the residual effects of previous orthopedic surgery (for partial ACL and Meniscus Tears), it confirmed the growing suspicion that aging athletes are fighting an uphill battle.


18/Oct/2018
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National Academy of Sciences - Knee Osteoarthritis

THE COMEBACK

How Elite Athletes Can Inspire Us

We look to super athletes for inspiration in how they train and win.  Yet it’s the injuries that show us their true character and grit, while also revealing their technical approach to healing and fighting the aging process. Video is further below...


While delivering a thundering double-handed backhand on the tennis court several years ago, legendary tennis player Rafael Nadal placed his entire weight on his left knee, forcing his quadriceps to step in and stabilize the entire complex of joints.

In that single moment, which involved twisting, turning and extending his body to relay the shot back to his opponent, he ripped his patellar tendon forcing him out of competition for several months.

Nadal backhand


Nadal Knee Injury on Tennis court


The Weight of a Champion

Around 1000 pounds of pressure was delivered to the knee joint just as the left heel struck the ground, causing an unbearable hyperextension of the knee just before bending.

Watch the Full Analysis

With the ACL and Medial Meniscus working overtime to compensate, Nadal felt a rush a of pain shoot into the fat pad around his knee.  The video below shows the tibia in a fixed position, with the femur still moving; a perfect recipe for disaster as Nadal goes into his fabled body rotation. 

The Layoffs

This injury turned out to be one of many for this hard-working athlete, with the most recent one coming during the quarterfinals of the Australian Open, forcing him to question the brutal regime of the ATP tour and whether his body can truly stand up to the effects of aging.

Weight on the Knee



Experiencing knee pain



Fear of Surgery

The biggest fear for athletes, especially once they go beyond the age of 30 is the looming spectre of surgery.  The risks, long-layoffs and indeterminate outcomes make them rightly weary, leading them to seek out the latest advances in medical science for alternatives,  

How Nadal Approaches Knee Rehabilitation

While they may be genetically gifted, athletes like Nadal are also cognizant of the subtle appearance of osteoarthritis or Degenerative Joint Disease  (DJD), giving them another area for concern.  Just like us, they cannot escape the affects of aging that escalate with a chronic knee injury. 

As you may expect, some of their solutions border on the space-age.  For instance, Its been reported that Nadal uses an anti-gravity treadmill machine to gently keep him in shape during injury layoffs, sparing his knee undue pressure and jolting.

Knee Rehab machine

However, it’s in the field of Regenerative Medicine that Nadal has often cast his gaze to seek an accelerated healing flight path, without the risks of surgery.  

For two consecutive years, Nadal specifically tested out PRP allowing him to recover 100% from a knee injury.    He also tried out stem cell therapy for his lower back, which we described in this recent sports medicine article several months ago.  

 It must be noted that while not every cellular treatment protocol has been 100% completely successful, Nadal recognizes that the procedures become more advanced and powerful each year, giving him greater opportunities to accelerate the knee rehabilitation process. 

Stem cells are influencing several areas of medicine,  including orthopedic procedures aimed at regenerating cartilage and producing an anti-inflammatory effect.  

Typically, this involves harvesting a patient's own bone marrow and fat cells to target joint damage, especially in the knees. 

Since Nadal may play close to 80 matches per year, each one grueling in intensity, there is a natural advantage to seeking out alternatives to surgery when injury strikes as per the video above.

“The schedule is crazy,” said Nadal.  “It’s crazy now, it was crazy before and it will still be crazy next year. You can’t make your body go to the limit for the whole year. It’s just not possible.”

To put his statement in perspective consider this statistic:  In 1992, the a ground-stroke reached roughly 60 m.p.h in the men’s game.  Today that speed may approach 100 m.p.h.

We are thus asking superhuman demands from our athletes. In return, they are asking for alternatives to surgery.  

While the video above demonstrates a specific injury to an elite athlete, the truth is any one of us reading this article may experience the same injury while running on the beach or playing catch with our grandson.  It could even happen at work while carrying a box up the stairs. 

But by observing the injury patterns we see on the tennis court and how super athletes respond to new forms of knee rehabilitation we can repurpose these approaches inside minimally invasive Stem Cell Procedures for our patients in Bonita Springs.

While none of us are machines, we can turn to science and technology to explore safer alternatives to surgery and a faster approach to healing the human body.  

Nobody is pursuing this approach more keenly that one of the world’s greatest tennis players, Rafael Nadal. Let's keep watching him - both on and off the court.


18/Oct/2018
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125 years ago the legendary Dr. Andrew Taylor Still, MD, founded Osteopathic Medicine, a profound turning point in modern medicine that ultimately led to the genesis of MedicalMasters.org. Please join me on this journey….

dr. steve coleman's credentials


Key medical milestones in his career as a physician.

1979

MEDICAL DEGREE

Michigan State University

Dr. Coleman received his undergraduate education at Michigan State University, laying a strong foundation in Internal Medicine.

1984

OSTEOPATHIC DEGREE​​​

Kirksville College of

Osteopathic Medicine.

He attended the Kirksville College of Osteopathic Medicine in Missouri, which was the very first school of osteopathic medicine in the world. 

2007

REGENERATIVE DIPLOMA

American Academy and Board of Regenerative Medicine, or AABRM

With certificate number 42, he was one the first physicians to become board certified by the American Academy and Board of Regenerative Medicine, or AABRM

Dr. Steve Coleman, D.O

If you are currently experiencing knee pain from a previous injury or sports-related trauma we may be able to help.
Please schedule a Comprehensive Medical Assessment (CMA) to determine if you qualify for promising new treatments
in Stem Cell Therapy, Prolotherapy and PRP.


18/Oct/2018
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Is there a hidden agent in the healing process which could enhance our understanding and treatment of knee osteoarthritis and knee joint sports injuries?  Our regenerative clinic believes this may well be the case as we absorb fascinating new research about special protein messengers in the human body we call Cytokines.

These signalling proteins are being watched closely by leading academics & practitioners exploring new frontiers in stem cell biology, including Dr. Coleman, D.O., who has recently announced the introduction of cytokines into MedicalMasters.org suite of regenerative cellular injection technologies related to healing knee joints, hip joints, shoulder joints, and lower back pain.

Time course of knee-joint swelling in rats with AIA used to evaluate cytokine mRNA. Values are means (n = 4 to 6); vertical bars indicate the standard error of the mean. The disease is characterized by rapid onset of acute inflammation, a peak on day 1, and a transition to chronicity on day 6. **P ≤ 0.01 in comparison with day 0; ++P ≤ 0.01 in comparison with the preceding date. AIA, antigen-induced arthritis.
A study publish in Research Gate related to the time course of knee-joint swelling in rats with AIA used to evaluate cytokine mRNA

This family of messenger proteins affect nearly every biological process in the human body including, but not limited to: infection response, embryonic development and the potential for inflammation in the joint space area around the knee.

The more we learn about cytokines the more we believe they create favorable conditions for the knee joint to heal faster when paired with autologous stem cells extracted from your own body, including fat and bone marrow cells.  While we may use technical terms to classify these micro-healers including peptides, glycoproteins, or proteins, in simple terms they have a powerful, local effect on hinge joints such as the knee and hip.

Of particular interest is the role pro-inflammatory cytokines and mediators play in the onset and progression of osteoarthritis. Conversely, we also have group of anti-inflammatory cytokines which do the opposite and reduce inflammation.     In other words, each time your knee painfully swells up after an injury (or gradually over time from the degenerative effects of osteoarthritis), we can partly trace the cause back to a group of “bad” cytokines, aptly labeled by my colleague Dr. Purita

The Scene of the Crime

Cytokines In Knee Osteoarthritis
This diagram explores role of obesity in aggravating osteoarthritis. It also examines how cytokines influence in the healing process.

We are learning how to manipulate both the good and bad cytokines in different approaches, all with the end goal of reducing knee pain and accelerating joint repair.   For patients with advanced osteoarthritis, we find higher levels of Interleukin 1 (IL-1) and Interleukin 6 (IL-6), two powerful cytokines in the human body that essentially “murder” good cells and produce a swelling effect in your knee or hip joint.   Joining them in this crime, is Tissue Necrosis Factor (TNF).

Cumulatively, these “bad” agents group together to halt joint repair at the cellular level.  These cytokines are immune to non-steroidal anti-inflammatory drugs.   By careful analysis of DNA synthesis, scientists have also discovered the heroes of our story, the so-called “good” cytokines which help reduce the swelling in your knee and promote joint healing.

Here Come The Good Guys

In recent years, stem cell tissue engineering studies of cytokines show that the cellular trafficking mechanisms described above also provide agents to fight the negative effects of joint inflammation.   These healing messenger proteins or “good” cytokines were first discovered in 1984 and appear to stimulate collagen growth that assist in healing knee cartilage.  In fact, they are key ingredients in stem cell therapy and cellular regeneration which we offer at our clinic.

While their names are technical and arcane, they are worth knowing since they may hold the key to getting you back on the tennis court faster or simply allowing you to walk pain free.  

Importantly, they have an effect similar to  “icing” a painful joint and play a role in tissue repair.  

Interluekin-1-Antogonist (AIL-1/IL-1A)

Interleukin 1 receptor antagonist Cytokines in Knee Joint

These agents help block the inflammatory effects of Interleukin 1 (IL-1) mentioned earlier.  They have other roles, too, but this particular healing effect is something scientists and doctors  are watching closely, including MedicalMasters.org.

Interluekin 10

Interleukin 10 (IL-10) Cytokines In Joint Inflammation

Researchers have noted the regulatory role that Interluekin 10 plays in a variety of human immune responses, including stimulating joint repair.  Specifically, it may prevent cellular damage and help maintain normal tissue homeostasis by reducing inflammation and joint destruction.

IGF-1

 IGF-1 Cytokine and Growth Factors in Anti Inflammation in Knee

For some time now, medical researchers have noted the potential therapeutic for cartilage repair exhibited by the “growth” cytokine, IGF-1, when injected intra-articularly into the knee joint.  While this approach is challenging, mainly due to the short half-life of this cytokine, significant progress has been made in recent years which suggest its beneficial use within stem cell therapy and other injection protocols, including PRP.   

The Dawn Of Maximum Joint Healing

The human body’s blood cells producing these cytokines are thus offering regenerative physicians a “united cellular front” to to stimulate cartilage repair while reducing inflammation using the power of active growth hormones such as IGF-1.  By countering the “bad” cytokines our cellular “good guys” inhibit the destructive proteins and stimulate key cell receptors which stimulate stem cells and PRP to build up new cartilage and tissue.

Our clinic is extremely excited by the introduction of Cytokine Medicine for knee osteoarthritis and sports injuries as it allows us to exceed the limitations of standard PRP by using a variety of messenger protein applications for the patient at more affordable prices than in the past.

Osteoarthritis stages for knee pain
The stages and effects of knee osteoarthritis and degenerative joint disease.

This means MedicalMasters.org will be able to offer patients hybrid cytokine treatments including oral tablets, injectables and transdermal creams, which will all work together as “cellular growth mechanisms” along with stem cell therapy and  Advanced PRP to promote joint and cartilage healing.   

It’s also important to realize that cytokines are increasingly being used as possible candidates for biochemical markers.  Both the “bad” (pro-inflammatory) and the “good” (anti-inflammatory) cytokines help determine the severity of osteoarthritis and degenerative joint disease and may act as both diagnostic and prognostic tools.

As Science Magazine recently stated,  we are in the midst of a major paradigm shift in how we think about treating disease and the regeneration of damaged tissues, with cytokines being the spear tip in this endeavor.

Ask Us About Cytokine Medicine in Knee Joint Repair

We invite all readers to inquire about the introduction of cytokine medicine into our stable of regenerative cellular injection tools including Stem Cell Therapy, PRP and Prolotherapy.    

Our same-day, minimally invasive orthopedic procedures are showing great promise for those suffering from knee pain, arthritis, and sports injuries (which include partial tears ofthe ACL, MCL tears and Meniscus).  Since we harvest the stem cells (autologously) from your own body there are no major issues with immunity or rejection. This combination of hematopoietic stem cells or bone marrow with mesenchymal stem cells found in fat tissue (adipose) help promote tissue and cartilage regeneration.  

Both of these sources are valuable but offer different advantages especially when paired with cytokine medicine.  By implementing a functional or integrative medicinal approach to patient healing we can tackle a number of soft tissue and cartilage injuries in the various joint areas.  These include shoulder bursitis, partial rotator cuff tears, tendonitis (including tennis elbow and achilles tendonitis) and aging-related knee joint issues.

Since cytokines are a key part of stem cell differentiation, we can now extend our capabilities further to minimize inflammation and stimulate tissue repair.

We expect Cytokine Medicine to become a powerful new tool in our regenerative clinic over the next few years and we look forward to sharing these results in upcoming patient success stories.

 


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18/Oct/2018
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One of the biggest challenges we see as regenerative medicine doctors, is the patient who has been suffering from joint paint for quite some time. Often these patients have had other more conservative therapy such as cortisone injections, anti-inflammatory medications, braces, therapy, and cortisone shots.

All, with no long term relief. I have heard many, many, patients say something very similar to the following:

“I got a cortisone shot and it was great for 3 days”

“The next time, It lasted for a couple of days”

The time after that , It did nothing”

If the patient waits even longer, and then sees a surgeon, they are frequently told “your only option is a total joint replacement

Don’t wait until it’s too late

This is unfortunate for the patient on many levels.

  • Total joint replacement is often curative for the Pain part of a serious joint degeneration. However, it carries other quite significant risks such as failed surgery, peri-operative infection, or blood clot risk. Not to mention cost to the patient and society.
  • The most serious risk to this surgery is of course :General anesthesia. Sometimes patients just don’t wake up from the procedure. A total disaster and a total loss.
  • The total dollars consumed is much, much higher for total joint replacement versus stem cell injection therapy ( total joints cost on average, 10 to 20 x as much as stem cell therapy)
  • A total joint replacement cannot by its nature, be a staged or stepped procedure. You either go all the way with a total joint replacement or you suffer on in silence.
  • With staged regenerative medicine procedures you can choose to treat more aggressively or less so, based on the patients needs and budget.
  • Pain medication therapy does nothing to change the course of the medical problem. It only treats the symptoms.
    This approach is fine in a morbid condition such as cancer or other fatal conditions. Is it appropriate for people who want or need to continue living? Only you and your family can answer that question.
  • Narcotics as an alternative to active treatment is quite a poor choice over time. You can only take narcotics for so long, before they stop working (Tachy-Phylaxis) or serious side effects rear their ugly head (overdose, loss of vitality and addiction)
  • Remember, there is virtually no risk to the surgeon who performs unnecessary surgery: the same cannot be said for the patient.
  • As an “Old School” Osteopathic Physician, I take my oath of Hippocrates, very seriously. See Plaque as given to me by Dr. James Clary, D.O. (circa 1960’s) upon his retirement.
  • It is much more logical to stop a damn when it begins to leak, than it is to wait until it completely washes out, and there is little foundation to build on.
  • I am not anti-surgery on any level. But I am totally for complete and informed choice for the patient. Who waits till the fire is through the roof before calling the fire department? Not I.
  • You as the patient, have the absolute right to demand what is best for your specific condition. One size does not fit all.

Don’t wait until it’s too late

  • Before you get to Bone on Bone, see a Regenerative Medicine Doctor.
  • Treat all medical problems before they become critical. It will save you time, money, grief and pain if you do.
  • I always put myself in the imagined position of the patient and ask, What is the best thing to do? Expect your doctor to do the same.  Would she or he, just let things go until a major surgery is the only option?

Always give your doctor the Mother Test:

Doctor, What would you do if I were your own mother?

That will give you the real answer to a true dilemma.


18/Oct/2018
knee-osteoahritis-and-stem-cell-therapy.jpeg

In the Mid-1950s something odd happened in the United States, that may force us to re-examine the links between aging, obesity and knee osteoarthritis - a condition that influences the quality of millions of Americans.

What is this peculiar event, you may ask?

Seven medical researchers have uncovered supporting evidence to show that prior to 1955, arthritic knees were rare - very rare. Suddenly, around this point in history, the disease began to double in prevalence.

Before going further consider for a moment that osteoarthritis will probably affect half our country during our lifetime, which is why we are approaching (and will soon exceed) 1 million knee replacement surgeries in the next 12 months. The research team’s findings  is thus critically important because presently the conventional wisdom suggests that living longer and higher obesity levels stimulate (and aggravate) the onset of osteoarthritis. They instead suggest there are several unconsidered variables that's leading to the growth of degenerative joint disease in the knee.


Even more fascinating is the conclusion that knee osteoarthritis may be more preventable than is commonly assumed.  They surmise that prevention will require research on additional independent risk factors that either arose or have become amplified in the postindustrial era. The researchers based their findings on autopsies of cadaver-derived skeletons of people aged aged below and above 50 whose BMI at death was documented .  These persons lived in the period spanning from the early industrial era (1800s to early 1900s) and the modern post industrial era (late 1900s to early 2000s).

National Academy of Sciences - Knee Osteoarthritis

 National Academy of Sciences 

Ian J. WallaceSteven WorthingtonDavid T. FelsonRobert D. JurmainKimberly T. WrenHeli MaijanenRobert J. Woods and Daniel E. Lieberman

quote-left

Whether increases in longevity and BMI (weight) are responsible for current knee OA levels has never been tested, but this assumption has led many to view the disease’s high prevalence as effectively unpreventable, since aging is untreatable, and the high BMI epidemic is intractable,” said the researchers in a paper delivered to the National Academy of Sciences.

They conclude that recent environmental changes have played a principal role in the deterioration of our knees, not just the extra baggage you carry around your waist.   

Specifically, they point to human beings loading more external weight on their bodies during daily activities; NOT weight gain (or high BMI) over time as a main contributor to knee arthritis.

There is an important inflection point, however, in their findings above.   


It’s not just that we are loading more weight (than our ancestors) on our poor bodies, but that we are also doing this while being generally more physically inactive during the course of any calendar year.

“Less physically active individuals who load their joints less develop thinner cartilage with lower proteoglycan content as well as weaker muscles responsible for protecting joints by stabilizing them and limiting joint reaction forces,” said the researchers.

Growth of Knee Osteoarthritis Since 1950 in America

This is an extremely intriguing conclusion because it again points to how vital it has become for your Doctor to examine your body and lifestyle in totality, not just symptomatically.

Dr. Steve Coleman, D.O

If you are currently experiencing knee pain from a previous injury or sports-related trauma we may be able to help.
Please schedule a Comprehensive Medical Assessment (CMA) to determine if you qualify for promising new treatments
in Stem Cell Therapy, Prolotherapy and PRP.

We can infer from their research that chronic low-grade inflammation, exacerbated by physical inactivity, is further stimulated by modern diets rich in highly refined carbohydrates. It does not end there: Excessive adiposity (i.e. being severely overweight) can further magnify and accelerate loading-induced damage to joint tissues and may also directly affect knee OA pathogenesis.


It’s important to emphasize that this research is ongoing but the results thus far MUST be taken into account when a patient comes in for a Comprehensive Medical Assessment or 100 Point Health Score at our Bonita Springs Regenerative clinic which offers stem cell therapy as a possible treatment modality.  

Your entire personal history and lifestyle are key indicators of your present condition and what treatment options should be made available to you.  An effective prevention strategy will involve adjusting  your physical activity patterns and diets to approximate more closely the lifestyle conditions under which our species has evolved.

What we also take away from this study is that fairly recent increases in knee osteoarthritis during the last several decades cannot simply be considered an inevitable consequence of people living longer or having higher BMI.

The Wonders of the Knee Joint


“Susceptibility to knee OA and other mismatch diseases is undoubtedly influenced by intrinsic factors, including age, sex, and genes, but the historical and evolutionary perspective afforded by our data underscores that many modern cases of knee OA may be preventable,” said the researchers.


Your present job or occupation may also be playing a role in the degeneration of your knee joints.  Sitting in front of computers for long periods with no intermittent physical activity seems to suggest another contributing piece to the arthritic puzzle.

High Heels and Knee Osteoarthritis in Women

Things get even stranger when one considers gender-based causes for knee joint degradation.   One particular study suggests that osteoarthritis in women may be due to long (could we say, agonizing) periods wearing, walking and standing in high-heel shoes.

The study focused on 20 healthy women wearing high heel shoes and walking barefoot. The results showed a 23% increase in compressive force on the medial compartment of the knee and more pronounced pressure on the patellofemoral joint as a whole.  Thus, these “altered forces” may likely be having a degenerative effect on female (or whomever enjoys wearing high-heels generally) joints over time.


This new vein of research has been shared with you to illustrate just how subtle and intricate the human body behaves in the modern world.   Our present health system, and indeed our well being, can no longer be targeted with treatment plans that simply focus on limiting symptoms with the use of pharmacological agents.  
We also do not wish to suggest, based on the discussion above, that is now OK for you to keep or put on weight: This harmful condition will lead to a variety of other negative outcomes which may in turn influence the long-term health of the knee in unexpected ways.  Not to mention the havoc it plays on hormonal levels and the possible threat of diabetes!

It’s also worth considering the role walking on hard pavements plays in affecting the knee joint.   If you combine this activity with inactivity, we have further metrics to consider in the overall degeneration of the knee.

Further, simply pushing a patient to undergo knee or hip replacement surgery is also an unwise decision.  Evidence is mounting that we must find alternatives, especially if you consider recent recommendations from major bodies such as the Australian Rheumatology Association which said that arthroscopic knee surgery to treat osteoarthritis is of low value and doctors are being told to consider alternatives such as exercise therapy to avoid unnecessary harm to the patient.

These recommendations were supported by the country’s Consumer Health Forum.

This is a major reason why we continue to study new trends in joint stem cell therapy research and its application for qualified patients experiencing knee pain from osteoarthritis.  While stem cell therapy will not work for everyone, it shows remarkable promise for patients whose osteoarthritis is not yet bone on bone.   For those interested in FTC/FDA-compliant stem cell therapy, please read this recent patient success story for Marie Claire, who experienced a positive outcome after undergoing the short, same-day procedure which utilized her body’s own cells, including fat and bone marrow, to stimulate healing in the knee joint.

Our medical clinic continues to use the best tenets of osteopathic medicine to situate the patient within his present lifestyle, medical history and physiological condition.  As the earlier study pointed out, environmental factors play a key role in your present condition.   It also means that doctors, surgeons and specialists - including us - need to constantly re-examine our belief systems and the incoming science with regards why a patient is experiencing osteoarthritis AND how we should treat it.

Tackling Knee Osteoarthritis in  Bonita Springs

We hope found the article above informative, helping you to make more informed decisions regarding your health, especially if you are experiencing knee pain in Bonita Springs.  Feel free to reach out to us and ask any health questions on your mind.  We also offer treatment options for #osteoarthritis in the knee and hip joints.