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22/Jun/2018
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While not immediately obvious, there is a wonderful and powerful mechanism at work which is bringing Osteopathic Doctors, Physical Therapists and bold Medical Device Inventors together in a synergistic movement to treat, heal and alleviate chronic pain in joint pain sufferers across the world in what we call the Golden Age of Regenerative Medicine.

Doctors of Regeneration

Dr Steve Coleman Stem Cell Therapy

Few people realize that our discipline has been around for some 100 years, tasked with treating acute injuries, chronic diseases like osteoarthritis and congenital malformations.  With the latest breakthroughs in stem cell biology, regenerative clinics offer new viable hope in providing alternatives to invasive knee, hip, lower back or shoulder surgeries.   Our field continues to grow, and we are finding new partners and champions in the form of physical therapists and medical device inventors who seek to complement our treatment plans with their own skill sets.  This is the backbone of functional medicine, treating the body as a whole and using new, dynamic and scientific approaches to orthopedic healing.    By keeping an open mind, we can adapt faster to the ravages of age, disease and injury.

The Evolving Physical Therapist

Physical Rehab For Stem Cell Patients

We cannot forget the role physical therapists play in regenerative medicine, especially after patients undergo stem cell procedures, including PRP and Prolotherapy, for joint pain, osteoarthritis (OA), and annular tears (rips in the tough exterior of an intervertebral disc).

This role requires compassion, knowledge and an intricate understanding of the muscular-skeletal system as they help patients mobilize all the key muscles and hinge-joints to accelerate the healing process.

Since our clinic is built upon the science of osteopathic medicine we pay particular attention to the physical rehabilitation process, working closely with select therapists to coordinate a careful, biomechanical flightpath to speedy recovery.

The best results for our patients come by combining rest, correct biomechanical loading, tissue mobilization and various other protocols to gently and methodically guide patients to maximum mobility and skeletal function in the period after the initial stem cell injections.

We also pay close attention to the objectives and goals defined by the Alliance for Regenerative Rehabilitation Research and Training which seeks to foster and nurture a strong collaborative relationship between Osteopathic Doctors such as Dr. Steve Coleman (D.O), Founder of MedicalMasters.org and other Physical Therapist partners, including those operating in and around Bonita Springs.

By educating PT’s on stem cell biology and regenerative medicine protocols, the treatment options available to our patients become more powerful and effective over shorter periods. The AR3T is thus an instrumental body in helping align the groundbreaking medical procedures being implemented by MedicalMasters.org and the evolving rehabilitative structures and processes of nearby physical therapy centers.

We remind our readers that regenerative medicine is currently evolving at a dramatic pace promising to greatly improve the methods and tools for repairing or replacing lost tissue from injury, disease or age via the enhancement of endogenous stem cell function or the transplantation of exogenous stem cells. By working closely with PT’s, we improve the application of mechanical and other physical stimuli to promote functional recovery.

These synergies are something we are extremely excited about and believe will become more advanced and integrated over time as we grow as a regenerative clinic.

But, while our partnership with physical therapists and physical rehabilitation centers is an important component of the regenerative landscape, we sometimes fail to mention other innovators in our realm who use the power of entrepreneurship and compassion to introduce new medical devices that hold the hope of helping you heal faster without the need for invasive surgery.

We are of course talking about medical device inventors, some of them very ordinary people who either suffer from the affliction of degenerative joint disease (DJD) or have a close relationship with somebody who does. In nearly all instances, their personal desire to alleviate suffering ends up having worldwide implications for other sufferers in the form of relief and hope.

In this respect, let’s examine two everyday inventors on opposite sides of the world, Hong Kong and Minnesota respectively, whose devices hold some hope for alleviating the pain and discomfort relating to arthritic joints. Their journey from idea to production, is both heart-warming and relevant. It is also an inspiration to us all, revealing how human ingenuity can transform our daily lives if we use the power of observation.

From Hong Kong With Love

Knee Warmer for arthritic knee


Our first intrepid inventor is located in Hong Kong who could not stand the sight of his elderly dad in agonizing pain stemming from arthritic knees. For years he watched his dad struggle to walk properly, his gait despairingly altered by the effects of osteoarthritis.   Each night, without fail, he would apply a heating pad upon his knee to ease the pain and stimulate mobility. Unfortunately, a few minutes later it would cool off prompting him to ask his wife or son to help him heat it up again. This scenario played out night after night. Surely, Stanley Kwok Chi-Hung thought to himself, there must be a better way.

He had to help his poor dad.

As fortune would have it, Mr. Chi-Hung happened to co-own KnitWarm, a manufacturing company. He brainstormed some ideas with his staff even while he noted that most manufacturing work was increasingly heading to mainland China.

After months of prototyping his team came up with a knee-heating wrap with a special breathable yearn that can be produced without extensive knitting, fully formed.

It is in many respects a breakthrough product for not only helping his ailing dad’s knees but also to a region that is aging quickly leading to a large spike in joint pain sufferers.

In fact, a recent study suggests that among local residents aged 50 and older, 7 per cent of men and 13 per cent of women suffer from osteoarthritis – an age-related condition that causes excruciating pain in the knee and other joints.

Within the next several years these numbers are expected to rise dramatically. The South China Posts reports that some 21 per cent of local residents are expected to be 65 or older, showing the connection to increasing levels of osteoarthritis.

Yet as long as we have compassionate inventors like Mr. Chi-Hung, the field of regenerative medicine can arm itself with more weapons to fight chronic joint pain without necessarily resorting to risky surgery.

The Minnesota Violinist With Healing Strings To Her Bow

Sarah Betts - Regenerative Medicine Inventor
Sarah Betts Playing Violin -future future

Our next inventor, and much closer to home this time, is a young violinist from Mendota Heights, Minnesota, who happily plucked those musical strings from three years old until she was diagnosed with Rheumatoid Arthritis at age nine.

The condition was especially prominent in her hands and wrist joints, but she refused to let this stop her from pursuing her musical vocation.

Normally, arthritis only affects those much older. Sarah Betts was indeed unlucky, but she used this misfortune to become a medical entrepreneur.

As time went on Sarah noticed that the more she played her violin, the less pain and swelling her left hand that presses the strings appeared to have compared to her right hand that holds the bow.

This, she thought to herself, was a surprising discovery. Most of the doctors and experts who examined her seemed to have missed this development.

This curiosity became the genesis for a new device she invented to help strengthen and mobilize the joints in the right hand.

She coined the orthopedic hand exercise device, ViEx, and industrially went about securing two patents for her medical invention.

"It has recycled violin strings that you can press down on top of a 3D printed base. Exercises take 10 minutes a day," she said.

The device is now being trialed at several orthopedic centers and received glowing reviews from onsite staff.

Now aged eighteen she has even built up an outreach programs to help the elderly benefit from her device.

"One lady, she could barely open her hand. Now, she's been using it for about a year and a half, and I mean, she can move her hand," Sarah said.

The device is highly affordable, priced at a paltry $3, but the young lady believes she make it even cheaper! See in her action below at a statewide graduation recital - she is quite impressive. 

An Intersection of Science, Hope & Entrepreneurship

The preceding discussion shows the symbiotic relationship between osteopathic clinics, cellular treatment breakthroughs, physical rehabilitation and the allied contributions of medical device inventors in America and elsewhere.

The most advanced stem cell treatment protocols rely on using a functional approach to guide the initial Comprehensive Medical Assessment (CMA) and combine with physical therapists to develop a holistic treatment plan that will give the fastest and most productive healing approach for our patients.

The three circles of regenerative medicine

 But we must also be proactive and find new ancillary - often simple tools - that aid in this process.   In this respect, we watch the medical device field closely and cheer the progress of inventors like Kwok in Hong Kong and Sarah in Minnesota who used the power of observation and love to combat the awful effects of arthritis that plague all of us as we age.

If there is a commonality among the three approaches mentioned above, it is probably compassion.  Without this attribute we cannot develop careful approaches that meets the individual’s own unique physiology and medical history.

This is the driving force behind regenerative medicine which has now entered a new golden age of research, development and treatment protocols that we believe hold the key to aging gracefully without pain,  while still enjoying a high degree of mobility.




22/Jun/2018
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BONITA SPRINGS Florida, May 16, 2018 /MedicalMasters.org/ —  Patients who need Stem Cell Therapy treatments targeting joint pain, osteoarthritis and more, can now leverage a new range of flexible financing options offering them all access to the promise of hope in Regenerative Medicine.

The updated programs offer near-instant approval and full access to the experts in regenerative medicine at MedicalMasters.org.  This includes the full range of medical programs provided by Dr. Coleman and his dedicated staff, including Advanced Cellular Therapies, Hormone balancing, Varicose Vein Treatment and Intravenous nutritional support.

“We are offering two comprehensive plans to begin with for our patients, from industry leaders ClearGage and MD Funding.  Soon, we expect to roll out additional affordable partners in the coming months to give our patients, friends, and families unparalleled access to preventive and regenerative medicine from coast to coast in Florida,  and world wide, with our concierge travel medicine program” said Dr. Steven Coleman D.O., founder of MedicalMasters.org.

The financing plans are available to patients in all 50 states, confirming our commitment  at MedicalMasters.org, to advancing the health and wellness of everyone who needs our help.  The plans allow a patient to pay for medical procedures over a time frame that suits their own needs. This can be  monthly payments, or larger payments that meet their goals. Approvals take less than a minute, and only require a valid driver’s license and  social security number. The plans cost far less than half of most credit card fees and all who need them are approved.

Additionally, the plans do not require that patients use current available credit  – these can be saved for home mortgage use, or other important goals such as their children’s education.   

“As our patients’ needs change, they can add additional care to their existing plans, or simply pay them off completely, with no penalty —  making this an extremely attractive option for patients of all ages, and all income levels” said Dr. Coleman.

In addition, the initial Comprehensive Medical Assessment  (100 Point Health Score evaluation) is already covered by every health insurance plan, offering patients a powerful platform through which they can pursue optimal well-being as they sail past the age of 40.  Patients are invited to inquire about these financing options by reaching out to us via our contact page. 


22/Jun/2018
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When a former college football quarterback, with letters in 3 sports, throughout high school, walked through our doors complaining of chronic pain in both knees due to previous sports injuries, and the residual effects of previous orthopedic surgery (for partial ACL and Meniscus Tears), it confirmed the growing suspicion that aging athletes are fighting an uphill battle.


22/Jun/2018
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National Academy of Sciences - Knee Osteoarthritis

THE COMEBACK

How Elite Athletes Can Inspire Us

We look to super athletes for inspiration in how they train and win.  Yet it’s the injuries that show us their true character and grit, while also revealing their technical approach to healing and fighting the aging process. Video is further below...


While delivering a thundering double-handed backhand on the tennis court several years ago, legendary tennis player Rafael Nadal placed his entire weight on his left knee, forcing his quadriceps to step in and stabilize the entire complex of joints.

In that single moment, which involved twisting, turning and extending his body to relay the shot back to his opponent, he ripped his patellar tendon forcing him out of competition for several months.

Nadal backhand


Nadal Knee Injury on Tennis court


The Weight of a Champion

Around 1000 pounds of pressure was delivered to the knee joint just as the left heel struck the ground, causing an unbearable hyperextension of the knee just before bending.

Watch the Full Analysis

With the ACL and Medial Meniscus working overtime to compensate, Nadal felt a rush a of pain shoot into the fat pad around his knee.  The video below shows the tibia in a fixed position, with the femur still moving; a perfect recipe for disaster as Nadal goes into his fabled body rotation. 

The Layoffs

This injury turned out to be one of many for this hard-working athlete, with the most recent one coming during the quarterfinals of the Australian Open, forcing him to question the brutal regime of the ATP tour and whether his body can truly stand up to the effects of aging.

Weight on the Knee



Experiencing knee pain



Fear of Surgery

The biggest fear for athletes, especially once they go beyond the age of 30 is the looming spectre of surgery.  The risks, long-layoffs and indeterminate outcomes make them rightly weary, leading them to seek out the latest advances in medical science for alternatives,  

How Nadal Approaches Knee Rehabilitation

While they may be genetically gifted, athletes like Nadal are also cognizant of the subtle appearance of osteoarthritis or Degenerative Joint Disease  (DJD), giving them another area for concern.  Just like us, they cannot escape the affects of aging that escalate with a chronic knee injury. 

As you may expect, some of their solutions border on the space-age.  For instance, Its been reported that Nadal uses an anti-gravity treadmill machine to gently keep him in shape during injury layoffs, sparing his knee undue pressure and jolting.

Knee Rehab machine

However, it’s in the field of Regenerative Medicine that Nadal has often cast his gaze to seek an accelerated healing flight path, without the risks of surgery.  

For two consecutive years, Nadal specifically tested out PRP allowing him to recover 100% from a knee injury.    He also tried out stem cell therapy for his lower back, which we described in this recent sports medicine article several months ago.  

 It must be noted that while not every cellular treatment protocol has been 100% completely successful, Nadal recognizes that the procedures become more advanced and powerful each year, giving him greater opportunities to accelerate the knee rehabilitation process. 

Stem cells are influencing several areas of medicine,  including orthopedic procedures aimed at regenerating cartilage and producing an anti-inflammatory effect.  

Typically, this involves harvesting a patient's own bone marrow and fat cells to target joint damage, especially in the knees. 

Since Nadal may play close to 80 matches per year, each one grueling in intensity, there is a natural advantage to seeking out alternatives to surgery when injury strikes as per the video above.

“The schedule is crazy,” said Nadal.  “It’s crazy now, it was crazy before and it will still be crazy next year. You can’t make your body go to the limit for the whole year. It’s just not possible.”

To put his statement in perspective consider this statistic:  In 1992, the a ground-stroke reached roughly 60 m.p.h in the men’s game.  Today that speed may approach 100 m.p.h.

We are thus asking superhuman demands from our athletes. In return, they are asking for alternatives to surgery.  

While the video above demonstrates a specific injury to an elite athlete, the truth is any one of us reading this article may experience the same injury while running on the beach or playing catch with our grandson.  It could even happen at work while carrying a box up the stairs. 

But by observing the injury patterns we see on the tennis court and how super athletes respond to new forms of knee rehabilitation we can repurpose these approaches inside minimally invasive Stem Cell Procedures for our patients in Bonita Springs.

While none of us are machines, we can turn to science and technology to explore safer alternatives to surgery and a faster approach to healing the human body.  

Nobody is pursuing this approach more keenly that one of the world’s greatest tennis players, Rafael Nadal. Let's keep watching him - both on and off the court.


22/Jun/2018
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Ahh, time flies by.   Those vintage days back in the 50s, 60s and 70s were some of of the fondest and brightest moments of our life, where we pursued our passions, hobbies, sports and laid the foundations of who we are NOW as human beings.

Cellular Therapies

Time Left To Stem Cell Therapy Seminar

​Event is sold out and will begin shortly. Click the link below to read more about what attendees will learn in the  seminar, including treating #Osteoarthritis #SportsInjuries and #JointPain With #StemCellTherapy.

Lets Wind Back The Clock With Regenerative Medicine

Your silent and unwavering supporters during these golden years,  and up to the present day, were your #Joints and #Hormones.

Your Knee Joints went into battle for you each time you played a game of tennis or went water skiing on those magical sun-kissed days.  Your hormones, including estrogen in woman and testosterone in men, helped balance your moods and gave you energy to hike up that mountain with friends.

Now, as a seasoned veteran of life you boast decades of experience and the joy of marriage, family, friendship and community.  But because you have lived a full life your faithful servants including your hip and shoulder joints may no longer service you the way they did way back in the day.  You may also feel less sprightly and perhaps suffer from sleepless nights due to wavering hormone levels or the affects of joint pain.

But Where There is Life, There is Hope.

Experience the miracle of #RegenerativeMedicine and take one step closer to reclaiming a full and rich life where your knee and hip joints no longer ache and your mood, energy and outlook on life are balanced and optimized.

We are here to give back to your faithful servants, your unwavering supporters, those wonderful mechanisms and structures inside the human body which carried you through life.

It is our privilege and honor to offer you family-oriented healthcare using science and research to guide our treatment plans, built upon the foundations of hope and empathy.

Try One Last Time...

If you feel full of despair, like life is against you, or you experience pain walking up stairs and the frustration of fatigue when you march through the day, then its time to “try one last time” to find a solution.

That “One Last Time” is MedicalMasters.org, a clinic built upon the foundations of Osteopathic Medicine and currently pioneering new treatments in Cellular  Medicine, including Stem Cell Therapy, Hormone Balancing and Nutritional Counseling.

Your journey through life is our journey, too, and we will always be here for you, no matter what stage of life you currently find yourself in. 

100 POINT HEALTH SCORE

When you are ready to take the next step in your journey towards optimum health, please schedule a Comprehensive Medical Assessment, CMA, with Dr. Coleman, a Doctor of Osteopathic Medicine, and an expert in Regenerative Medicine. 


22/Jun/2018
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125 years ago the legendary Dr. Andrew Taylor Still, MD, founded Osteopathic Medicine, a profound turning point in modern medicine that ultimately led to the genesis of MedicalMasters.org. Please join me on this journey….

dr. steve coleman's credentials


Key medical milestones in his career as a physician.

1979

MEDICAL DEGREE

Michigan State University

Dr. Coleman received his undergraduate education at Michigan State University, laying a strong foundation in Internal Medicine.

1984

OSTEOPATHIC DEGREE​​​

Kirksville College of

Osteopathic Medicine.

He attended the Kirksville College of Osteopathic Medicine in Missouri, which was the very first school of osteopathic medicine in the world. 

2007

REGENERATIVE DIPLOMA

American Academy and Board of Regenerative Medicine, or AABRM

With certificate number 42, he was one the first physicians to become board certified by the American Academy and Board of Regenerative Medicine, or AABRM

Dr. Steve Coleman, D.O

If you are currently experiencing knee pain from a previous injury or sports-related trauma we may be able to help.
Please schedule a Comprehensive Medical Assessment (CMA) to determine if you qualify for promising new treatments
in Stem Cell Therapy, Prolotherapy and PRP.


22/Jun/2018
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Thursday, August 3, 2017:  Dr. Steve Coleman, D.O., Medical Director of MedicalMasters.org has announced the immediate introduction of ground-breaking Cytokine Medicine into his suite of Regenerative Cellular Therapies, including Stem Cell Treatment, that promises to simultaneously reduce swelling in knee joints and stimulate cartilage repair for those suffering from osteoarthritis and sports injuries.

Recent medical studies suggest Cytokines, a group of messenger proteins in the body, affect nearly every biological process in the human body including the potential for inflammation in the joint space area around the knee.     

By pairing select Cytokines with Stem Cell Therapy and PRP, MedicalMasters.org aims to shorten the healing process for knees suffering from Degenerative Joint Disease (DJD) and sports injuries that are not yet bone-on-bone.  Read full article of benefits of Cytokine Medicine on MedicalMasters.org

Future Cytokine Protocols will be available in a variety of delivery methods including oral, injectables, and transdermal creams, that will supplement the Stem Cell Therapy process and target chronic inflammation in the body.

While the short term goal is to reduce pain and speed up joint repair, the long term goal is to minimize knee replacement surgeries in the United States that are approaching 1 million per year.  The risks inherent in invasive surgery were highlighted on MedicalMasters.org recently.

“Cytokine proteins are being heralded as a breakthrough biological process in reducing joint inflammation and helping cartilage repair itself.    The introduction to our clinic will offer monumental benefits to both aging patients and athletes who suffer injuries on the playing field or tennis courts,” said Dr. Steve Coleman.


22/Jun/2018
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Is there a hidden agent in the healing process which could enhance our understanding and treatment of knee osteoarthritis and knee joint sports injuries?  Our regenerative clinic believes this may well be the case as we absorb fascinating new research about special protein messengers in the human body we call Cytokines.

These signalling proteins are being watched closely by leading academics & practitioners exploring new frontiers in stem cell biology, including Dr. Coleman, D.O., who has recently announced the introduction of cytokines into MedicalMasters.org suite of regenerative cellular injection technologies related to healing knee joints, hip joints, shoulder joints, and lower back pain.

Time course of knee-joint swelling in rats with AIA used to evaluate cytokine mRNA. Values are means (n = 4 to 6); vertical bars indicate the standard error of the mean. The disease is characterized by rapid onset of acute inflammation, a peak on day 1, and a transition to chronicity on day 6. **P ≤ 0.01 in comparison with day 0; ++P ≤ 0.01 in comparison with the preceding date. AIA, antigen-induced arthritis.
A study publish in Research Gate related to the time course of knee-joint swelling in rats with AIA used to evaluate cytokine mRNA

This family of messenger proteins affect nearly every biological process in the human body including, but not limited to: infection response, embryonic development and the potential for inflammation in the joint space area around the knee.

The more we learn about cytokines the more we believe they create favorable conditions for the knee joint to heal faster when paired with autologous stem cells extracted from your own body, including fat and bone marrow cells.  While we may use technical terms to classify these micro-healers including peptides, glycoproteins, or proteins, in simple terms they have a powerful, local effect on hinge joints such as the knee and hip.

Of particular interest is the role pro-inflammatory cytokines and mediators play in the onset and progression of osteoarthritis. Conversely, we also have group of anti-inflammatory cytokines which do the opposite and reduce inflammation.     In other words, each time your knee painfully swells up after an injury (or gradually over time from the degenerative effects of osteoarthritis), we can partly trace the cause back to a group of “bad” cytokines, aptly labeled by my colleague Dr. Purita

The Scene of the Crime

Cytokines In Knee Osteoarthritis
This diagram explores role of obesity in aggravating osteoarthritis. It also examines how cytokines influence in the healing process.

We are learning how to manipulate both the good and bad cytokines in different approaches, all with the end goal of reducing knee pain and accelerating joint repair.   For patients with advanced osteoarthritis, we find higher levels of Interleukin 1 (IL-1) and Interleukin 6 (IL-6), two powerful cytokines in the human body that essentially “murder” good cells and produce a swelling effect in your knee or hip joint.   Joining them in this crime, is Tissue Necrosis Factor (TNF).

Cumulatively, these “bad” agents group together to halt joint repair at the cellular level.  These cytokines are immune to non-steroidal anti-inflammatory drugs.   By careful analysis of DNA synthesis, scientists have also discovered the heroes of our story, the so-called “good” cytokines which help reduce the swelling in your knee and promote joint healing.

Here Come The Good Guys

In recent years, stem cell tissue engineering studies of cytokines show that the cellular trafficking mechanisms described above also provide agents to fight the negative effects of joint inflammation.   These healing messenger proteins or “good” cytokines were first discovered in 1984 and appear to stimulate collagen growth that assist in healing knee cartilage.  In fact, they are key ingredients in stem cell therapy and cellular regeneration which we offer at our clinic.

While their names are technical and arcane, they are worth knowing since they may hold the key to getting you back on the tennis court faster or simply allowing you to walk pain free.  

Importantly, they have an effect similar to  “icing” a painful joint and play a role in tissue repair.  

Interluekin-1-Antogonist (AIL-1/IL-1A)

Interleukin 1 receptor antagonist Cytokines in Knee Joint

These agents help block the inflammatory effects of Interleukin 1 (IL-1) mentioned earlier.  They have other roles, too, but this particular healing effect is something scientists and doctors  are watching closely, including MedicalMasters.org.

Interluekin 10

Interleukin 10 (IL-10) Cytokines In Joint Inflammation

Researchers have noted the regulatory role that Interluekin 10 plays in a variety of human immune responses, including stimulating joint repair.  Specifically, it may prevent cellular damage and help maintain normal tissue homeostasis by reducing inflammation and joint destruction.

IGF-1

 IGF-1 Cytokine and Growth Factors in Anti Inflammation in Knee

For some time now, medical researchers have noted the potential therapeutic for cartilage repair exhibited by the “growth” cytokine, IGF-1, when injected intra-articularly into the knee joint.  While this approach is challenging, mainly due to the short half-life of this cytokine, significant progress has been made in recent years which suggest its beneficial use within stem cell therapy and other injection protocols, including PRP.   

The Dawn Of Maximum Joint Healing

The human body’s blood cells producing these cytokines are thus offering regenerative physicians a “united cellular front” to to stimulate cartilage repair while reducing inflammation using the power of active growth hormones such as IGF-1.  By countering the “bad” cytokines our cellular “good guys” inhibit the destructive proteins and stimulate key cell receptors which stimulate stem cells and PRP to build up new cartilage and tissue.

Our clinic is extremely excited by the introduction of Cytokine Medicine for knee osteoarthritis and sports injuries as it allows us to exceed the limitations of standard PRP by using a variety of messenger protein applications for the patient at more affordable prices than in the past.

Osteoarthritis stages for knee pain
The stages and effects of knee osteoarthritis and degenerative joint disease.

This means MedicalMasters.org will be able to offer patients hybrid cytokine treatments including oral tablets, injectables and transdermal creams, which will all work together as “cellular growth mechanisms” along with stem cell therapy and  Advanced PRP to promote joint and cartilage healing.   

It’s also important to realize that cytokines are increasingly being used as possible candidates for biochemical markers.  Both the “bad” (pro-inflammatory) and the “good” (anti-inflammatory) cytokines help determine the severity of osteoarthritis and degenerative joint disease and may act as both diagnostic and prognostic tools.

As Science Magazine recently stated,  we are in the midst of a major paradigm shift in how we think about treating disease and the regeneration of damaged tissues, with cytokines being the spear tip in this endeavor.

Ask Us About Cytokine Medicine in Knee Joint Repair

We invite all readers to inquire about the introduction of cytokine medicine into our stable of regenerative cellular injection tools including Stem Cell Therapy, PRP and Prolotherapy.    

Our same-day, minimally invasive orthopedic procedures are showing great promise for those suffering from knee pain, arthritis, and sports injuries (which include partial tears ofthe ACL, MCL tears and Meniscus).  Since we harvest the stem cells (autologously) from your own body there are no major issues with immunity or rejection. This combination of hematopoietic stem cells or bone marrow with mesenchymal stem cells found in fat tissue (adipose) help promote tissue and cartilage regeneration.  

Both of these sources are valuable but offer different advantages especially when paired with cytokine medicine.  By implementing a functional or integrative medicinal approach to patient healing we can tackle a number of soft tissue and cartilage injuries in the various joint areas.  These include shoulder bursitis, partial rotator cuff tears, tendonitis (including tennis elbow and achilles tendonitis) and aging-related knee joint issues.

Since cytokines are a key part of stem cell differentiation, we can now extend our capabilities further to minimize inflammation and stimulate tissue repair.

We expect Cytokine Medicine to become a powerful new tool in our regenerative clinic over the next few years and we look forward to sharing these results in upcoming patient success stories.

 


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22/Jun/2018
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One of the biggest challenges we see as regenerative medicine doctors, is the patient who has been suffering from joint paint for quite some time. Often these patients have had other more conservative therapy such as cortisone injections, anti-inflammatory medications, braces, therapy, and cortisone shots.

All, with no long term relief. I have heard many, many, patients say something very similar to the following:

“I got a cortisone shot and it was great for 3 days”

“The next time, It lasted for a couple of days”

The time after that , It did nothing”

If the patient waits even longer, and then sees a surgeon, they are frequently told “your only option is a total joint replacement

Don’t wait until it’s too late

This is unfortunate for the patient on many levels.

  • Total joint replacement is often curative for the Pain part of a serious joint degeneration. However, it carries other quite significant risks such as failed surgery, peri-operative infection, or blood clot risk. Not to mention cost to the patient and society.
  • The most serious risk to this surgery is of course :General anesthesia. Sometimes patients just don’t wake up from the procedure. A total disaster and a total loss.
  • The total dollars consumed is much, much higher for total joint replacement versus stem cell injection therapy ( total joints cost on average, 10 to 20 x as much as stem cell therapy)
  • A total joint replacement cannot by its nature, be a staged or stepped procedure. You either go all the way with a total joint replacement or you suffer on in silence.
  • With staged regenerative medicine procedures you can choose to treat more aggressively or less so, based on the patients needs and budget.
  • Pain medication therapy does nothing to change the course of the medical problem. It only treats the symptoms.
    This approach is fine in a morbid condition such as cancer or other fatal conditions. Is it appropriate for people who want or need to continue living? Only you and your family can answer that question.
  • Narcotics as an alternative to active treatment is quite a poor choice over time. You can only take narcotics for so long, before they stop working (Tachy-Phylaxis) or serious side effects rear their ugly head (overdose, loss of vitality and addiction)
  • Remember, there is virtually no risk to the surgeon who performs unnecessary surgery: the same cannot be said for the patient.
  • As an “Old School” Osteopathic Physician, I take my oath of Hippocrates, very seriously. See Plaque as given to me by Dr. James Clary, D.O. (circa 1960’s) upon his retirement.
  • It is much more logical to stop a damn when it begins to leak, than it is to wait until it completely washes out, and there is little foundation to build on.
  • I am not anti-surgery on any level. But I am totally for complete and informed choice for the patient. Who waits till the fire is through the roof before calling the fire department? Not I.
  • You as the patient, have the absolute right to demand what is best for your specific condition. One size does not fit all.

Don’t wait until it’s too late

  • Before you get to Bone on Bone, see a Regenerative Medicine Doctor.
  • Treat all medical problems before they become critical. It will save you time, money, grief and pain if you do.
  • I always put myself in the imagined position of the patient and ask, What is the best thing to do? Expect your doctor to do the same.  Would she or he, just let things go until a major surgery is the only option?

Always give your doctor the Mother Test:

Doctor, What would you do if I were your own mother?

That will give you the real answer to a true dilemma.


22/Jun/2018
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In the Mid-1950s something odd happened in the United States, that may force us to re-examine the links between aging, obesity and knee osteoarthritis - a condition that influences the quality of millions of Americans.

What is this peculiar event, you may ask?

Seven medical researchers have uncovered supporting evidence to show that prior to 1955, arthritic knees were rare - very rare. Suddenly, around this point in history, the disease began to double in prevalence.

Before going further consider for a moment that osteoarthritis will probably affect half our country during our lifetime, which is why we are approaching (and will soon exceed) 1 million knee replacement surgeries in the next 12 months. The research team’s findings  is thus critically important because presently the conventional wisdom suggests that living longer and higher obesity levels stimulate (and aggravate) the onset of osteoarthritis. They instead suggest there are several unconsidered variables that's leading to the growth of degenerative joint disease in the knee.


Even more fascinating is the conclusion that knee osteoarthritis may be more preventable than is commonly assumed.  They surmise that prevention will require research on additional independent risk factors that either arose or have become amplified in the postindustrial era. The researchers based their findings on autopsies of cadaver-derived skeletons of people aged aged below and above 50 whose BMI at death was documented .  These persons lived in the period spanning from the early industrial era (1800s to early 1900s) and the modern post industrial era (late 1900s to early 2000s).

National Academy of Sciences - Knee Osteoarthritis

 National Academy of Sciences 

Ian J. WallaceSteven WorthingtonDavid T. FelsonRobert D. JurmainKimberly T. WrenHeli MaijanenRobert J. Woods and Daniel E. Lieberman

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Whether increases in longevity and BMI (weight) are responsible for current knee OA levels has never been tested, but this assumption has led many to view the disease’s high prevalence as effectively unpreventable, since aging is untreatable, and the high BMI epidemic is intractable,” said the researchers in a paper delivered to the National Academy of Sciences.

They conclude that recent environmental changes have played a principal role in the deterioration of our knees, not just the extra baggage you carry around your waist.   

Specifically, they point to human beings loading more external weight on their bodies during daily activities; NOT weight gain (or high BMI) over time as a main contributor to knee arthritis.

There is an important inflection point, however, in their findings above.   


It’s not just that we are loading more weight (than our ancestors) on our poor bodies, but that we are also doing this while being generally more physically inactive during the course of any calendar year.

“Less physically active individuals who load their joints less develop thinner cartilage with lower proteoglycan content as well as weaker muscles responsible for protecting joints by stabilizing them and limiting joint reaction forces,” said the researchers.

Growth of Knee Osteoarthritis Since 1950 in America

This is an extremely intriguing conclusion because it again points to how vital it has become for your Doctor to examine your body and lifestyle in totality, not just symptomatically.

Dr. Steve Coleman, D.O

If you are currently experiencing knee pain from a previous injury or sports-related trauma we may be able to help.
Please schedule a Comprehensive Medical Assessment (CMA) to determine if you qualify for promising new treatments
in Stem Cell Therapy, Prolotherapy and PRP.

We can infer from their research that chronic low-grade inflammation, exacerbated by physical inactivity, is further stimulated by modern diets rich in highly refined carbohydrates. It does not end there: Excessive adiposity (i.e. being severely overweight) can further magnify and accelerate loading-induced damage to joint tissues and may also directly affect knee OA pathogenesis.


It’s important to emphasize that this research is ongoing but the results thus far MUST be taken into account when a patient comes in for a Comprehensive Medical Assessment or 100 Point Health Score at our Bonita Springs Regenerative clinic which offers stem cell therapy as a possible treatment modality.  

Your entire personal history and lifestyle are key indicators of your present condition and what treatment options should be made available to you.  An effective prevention strategy will involve adjusting  your physical activity patterns and diets to approximate more closely the lifestyle conditions under which our species has evolved.

What we also take away from this study is that fairly recent increases in knee osteoarthritis during the last several decades cannot simply be considered an inevitable consequence of people living longer or having higher BMI.

The Wonders of the Knee Joint


“Susceptibility to knee OA and other mismatch diseases is undoubtedly influenced by intrinsic factors, including age, sex, and genes, but the historical and evolutionary perspective afforded by our data underscores that many modern cases of knee OA may be preventable,” said the researchers.


Your present job or occupation may also be playing a role in the degeneration of your knee joints.  Sitting in front of computers for long periods with no intermittent physical activity seems to suggest another contributing piece to the arthritic puzzle.

High Heels and Knee Osteoarthritis in Women

Things get even stranger when one considers gender-based causes for knee joint degradation.   One particular study suggests that osteoarthritis in women may be due to long (could we say, agonizing) periods wearing, walking and standing in high-heel shoes.

The study focused on 20 healthy women wearing high heel shoes and walking barefoot. The results showed a 23% increase in compressive force on the medial compartment of the knee and more pronounced pressure on the patellofemoral joint as a whole.  Thus, these “altered forces” may likely be having a degenerative effect on female (or whomever enjoys wearing high-heels generally) joints over time.


This new vein of research has been shared with you to illustrate just how subtle and intricate the human body behaves in the modern world.   Our present health system, and indeed our well being, can no longer be targeted with treatment plans that simply focus on limiting symptoms with the use of pharmacological agents.  
We also do not wish to suggest, based on the discussion above, that is now OK for you to keep or put on weight: This harmful condition will lead to a variety of other negative outcomes which may in turn influence the long-term health of the knee in unexpected ways.  Not to mention the havoc it plays on hormonal levels and the possible threat of diabetes!

It’s also worth considering the role walking on hard pavements plays in affecting the knee joint.   If you combine this activity with inactivity, we have further metrics to consider in the overall degeneration of the knee.

Further, simply pushing a patient to undergo knee or hip replacement surgery is also an unwise decision.  Evidence is mounting that we must find alternatives, especially if you consider recent recommendations from major bodies such as the Australian Rheumatology Association which said that arthroscopic knee surgery to treat osteoarthritis is of low value and doctors are being told to consider alternatives such as exercise therapy to avoid unnecessary harm to the patient.

These recommendations were supported by the country’s Consumer Health Forum.

This is a major reason why we continue to study new trends in joint stem cell therapy research and its application for qualified patients experiencing knee pain from osteoarthritis.  While stem cell therapy will not work for everyone, it shows remarkable promise for patients whose osteoarthritis is not yet bone on bone.   For those interested in FTC/FDA-compliant stem cell therapy, please read this recent patient success story for Marie Claire, who experienced a positive outcome after undergoing the short, same-day procedure which utilized her body’s own cells, including fat and bone marrow, to stimulate healing in the knee joint.

Our medical clinic continues to use the best tenets of osteopathic medicine to situate the patient within his present lifestyle, medical history and physiological condition.  As the earlier study pointed out, environmental factors play a key role in your present condition.   It also means that doctors, surgeons and specialists - including us - need to constantly re-examine our belief systems and the incoming science with regards why a patient is experiencing osteoarthritis AND how we should treat it.

Tackling Knee Osteoarthritis in  Bonita Springs

We hope found the article above informative, helping you to make more informed decisions regarding your health, especially if you are experiencing knee pain in Bonita Springs.  Feel free to reach out to us and ask any health questions on your mind.  We also offer treatment options for #osteoarthritis in the knee and hip joints.